Subunit vaccine against flavivirus infection

Details Subunit vaccine against flavivirus infection Subunit vaccine against flavivirus infection

C - Chemistry, Metallurgy

12

N

C12N 15/79 (2006.01) A61K 39/12 (2006.01) C07K 14/18 (2006.01) C07K 16/10 (2006.01) C12N 5/16 (2006.01) C12N 15/40 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2224724

The invention provides vaccines capable of eliciting the production of neutralizing antibodies against flavivirus containing, as an active ingredient, a secreted recombinantly produced envelope protein or subunit thereof. In illustrative embodiments, the B domain or the 60 % or 80 % N-terminal portions of the envelope protein (E) of dengue virus are secreted. The secreted product can easily be purified and prepared as a vaccine.

L'invention porte sur des vaccins capables de provoquer la production d'anticorps de neutralisation à l'encontre d'un flavivirus contenant, en tant qu'ingrédient actif, une protéine d'enveloppe sécrétée, produite par recombinaison, ou une sous-unité de celle ci. Selon des modes de réalisation développant l'invention, le domaine B ou bien 60 ou 80 % des parties amino-terminales de la protéine d'enveloppe (E) du virus de la dengue sont sécrétés et ce produit sécrété peut être facilement purifié et préparé en tant que vaccin.

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