C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/18 (2006.01) A61K 31/506 (2006.01) A61P 25/28 (2006.01) C07D 211/22 (2006.01) C07D 211/26 (2006.01) C07D 211/42 (2006.01) C07D 211/58 (2006.01) C07D 211/60 (2006.01) C07D 213/38 (2006.01) C07D 239/42 (2006.01) C07D 241/20 (2006.01) C07D 295/185 (2006.01) C07D 317/58 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01)
Patent
CA 2404314
This invention relates to a novel succinoylamino heterocycles of Formula (I) having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.- peptide, thereby acting to prevent formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to .beta.-amyloid production such as Alzheimer's disease and Down's Syndrome.
Cette invention concerne des hétérocycles succinoylamino de Formule (I) possédant de propriétés pharmacologiques et une action biologique ainsi que leurs compositions et modes d'utilisation. Ces nouveaux composés inhibent la transformation de la protéine précurseur amyloïde et, plus spécifiquement, la production d'un bêta-peptide, ce qui empêche la formation de dépôts neurologiques de protéines amyloïdes. Plus précisément, cette invention concerne le traitement de troubles neurologiques en rapport avec la production bêta-amyloïde tels que la maladie d'Alzheimer et le syndrome de Down.
Kasireddy Padmaja
Thompson Lorin Andrew
Bristol-Myers Squibb Pharma Company
Dimock Stratton Llp
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