C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 223/12 (2006.01) A61K 31/55 (2006.01) C07D 243/24 (2006.01) C07D 401/06 (2006.01) C07D 401/10 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2338944
This invention relates to novel lactams of Formula (I) or a pharmaceutically acceptable salts or prodrug thereof, having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to .beta.-amyloid production such as Alzheimer's disease and Down's Syndrome.
La présente invention concerne de nouveaux lactames de la formule (I) ou leurs sels ou promédicaments acceptables du point de vue pharmaceutique, possédant des propriétés médicamenteuses et d'influence biologique, ainsi que leurs compositions pharmaceutiques et leurs méthodes d'utilisation. Ces nouveaux composés inhibent le traitement de la protéine précurseur amyloïde et, plus spécifiquement, la production de peptide A.beta., ce qui leur permet d'agir pour empêcher la formation de dépôts neurologiques de la protéine amyloïde. Plus particulièrement, la présente invention concerne le traitement de troubles neurologiques liés à la production d'amyloïde .beta., tels que la maladie d'Alzheimer et le syndrome de Down.
Maduskuie Thomas P.
Olson Richard E.
Thompson Lorin Andrew
Bristol-Myers Squibb Pharma Company
Dimock Stratton Llp
Du Pont Pharmaceuticals Company
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