Sugar base surfactant for nanocrystals

Details Sugar base surfactant for nanocrystals Sugar base surfactant for nanocrystals

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/51 (2006.01) A61K 47/26 (2006.01) A61K 49/04 (2006.01)

Patent

CA 2206430

Dispersible particles consisting essentially of a crystalline drug substance having a surface modifier having formula (I), wherein R is phenyl-(CH2)10CO or C12H25NHCO adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm, methods for the preparation of such particles and dispersions containing the particles. Pharmaceutical compositions containing the particles exhibit unexpected bioavailability and are useful in methods of treating mammals.

L'invention se rapporte à des particules dispersibles comprenant principalement une substance médicamenteuse crystalline possédant un modificateur de surface ayant la formule (I) dans laquelle R représente phényl-(CH¿2?)¿10?CO ou C¿12?H¿25?NHCO adsorbé sur la surface de cette substance, en une quantité suffisante pour maintenir une granulométrie moyenne effective inférieure à environ 400 nm. L'invention se rapport également à des procédés de préparation de ces particules et de dispersions contenant les particules. Des compositions pharmaceutiques contenant les particules présentent une biodisponibilité inattendue et sont utiles dans des procédés de traitement des mammifères.

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