Sugar chain-containing albumin, production method thereof...

Details Sugar chain-containing albumin, production method thereof... Sugar chain-containing albumin, production method thereof...

C - Chemistry, Metallurgy

12

N

C12N 15/14 (2006.01) A61K 38/38 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) C07K 14/76 (2006.01) C07K 14/765 (2006.01) C12N 15/12 (2006.01) C12N 15/79 (2006.01) C12N 15/81 (2006.01)

Patent

CA 2611540

Glycosylated albumin as a drug carrier for a DDS targeting the liver (particularly kupffer's cell) can be provided by mutating a DNA encoding albumin to encode a mutant albumin containing a partial amino acid sequence permitting glycosylation modification by eukaryotic cell, preferably a consensus sequence of N-linked sugar chain, introducing an expression vector containing the mutant DNA into a host eukaryotic cell, preferably a host cell permitting addition of a high-mannose type sugar chain, culturing the obtained transformant, and recovering a glycosylated albumin protein from the obtained culture.

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