C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/26 (2006.01) A61K 31/397 (2006.01) A61K 31/70 (2006.01) A61K 31/7052 (2006.01) A61K 45/06 (2006.01) C07D 205/08 (2006.01)
Patent
CA 2432798
Hypocholesterolemic sugar-substituted 2-azetidinone compounds of the formula: (see formula I) are disclosed, as well as a method of lowering cholesterol by administering said compounds, pharmaceutical compositions containing them, and the combination of a sugar-substituted 2-azetidinone cholesterol-lowering agent and a cholesterol biosynthesis inhibitor for the treatment and prevention of atherosclerosis.
L'invention concerne des composés hypocholestérolemiques de 2-azétidinone substitué par le sucre de la formule (I), ainsi qu'une méthode de réduction du cholestérol par administration desdits composés, de compositions pharmaceutiques contenant ces composés, et de la combinaison d'un hypocholestérolémiant à base de 2-azétidinone substitué par le sucre et d'un inhibiteur de biosynthèse du cholestérol pour le traitement et la prévention de athérosclérose.
Alton Kevin B.
Chowdhury Swapan K.
Davis Harry R.
Feng Wenqing
Ghosal Anima
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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