Sugar-substituted 2-azetidinones useful as...

C - Chemistry – Metallurgy – 07 – H

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C07H 15/26 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2235943

Hypocholesterolemic sugar-substituted 2-azetidinones are dislcosed, as well as a method of lowering cholesterol by administering said compounds, pharmaceutical compositions containing them, and the combination of a sugar- substituted 2-azetidinone cholesterol-lowering agent and a cholesterol biosynthesis inhibitor for the treatment and prevention of atherosclerosis.

L'invention concerne des 2-azétidinones substituées par un sucre et ayant un effet hypocholestérolémiant, ainsi qu'une méthode pour faire baisser le taux de cholestérol en administrant lesdits composés, des compositions les contenant, et l'association d'une 2-azétidinone substituée par un sucre, faisant baisser le cholestérol, et d'un inhibiteur de la biosynthèse du cholestérol, destinée au traitement et à la prévention de l'athérosclérose.

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