Suicide tetramers comprising mhc class i and uses thereof

Details Suicide tetramers comprising mhc class i and uses thereof Suicide tetramers comprising mhc class i and uses thereof

A - Human Necessities

61

K

A61K 38/00 (2006.01) C12N 5/077 (2010.01) C12N 5/078 (2010.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 47/48 (2006.01) A61K 51/04 (2006.01) A61K 51/08 (2006.01) C07K 14/74 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2487926

The present invention provides a cytotoxic MHC I conjugate comprising a cytotoxic moiety, biotinylated MHC I monomers which each comprise an antigenic peptide and streptavidin, bound to the cytotoxic moiety or to a biotinylated cytotoxic moiety and to the biotinylated MHC I monomers. Alternative constructs comprising a cytotoxic moiety and biotinylated MHC I monomers where each monomer comprises an antibody fragment also are provided. The cytotoxic moiety may comprise an 225Ac radionuclide or other cytotoxin. Further provided are methods of killing CD8+ T cell clonal populations.

La présente invention concerne un conjugué cytotoxique de CMH I comprenant une fraction cytotoxique, des monomères CMH I biotinylés comprenant chacun un peptide antigénique et de la streptavidine, liés à la fraction cytotoxique ou à une fraction cytotoxique biotinylée et aux monomères CMH I biotynilés. L'invention concerne également d'autres constructions qui comprennent une fraction cytotoxique et des monomères CMH I biotynilés, chacun de ces monomères comprenant un fragment d'anticorps. La fraction cytotoxique peut comprendre un radionucléide Ac-225 ou une autre cytotoxine. L'invention concerne également d'autres procédés permettant de tuer des populations clonales de cellules T CD8?+¿.

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