C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/12 (2006.01) A61K 31/445 (2006.01) A61K 31/453 (2006.01) A61P 19/00 (2006.01) C07D 211/46 (2006.01) C07D 211/66 (2006.01) C07D 309/08 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 491/10 (2006.01)
Patent
CA 2362230
A sulfamato hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a process for preparing the same, intermediate compounds useful in those syntheses, and a treatment process that comprises administering a contemplated sulfamato hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.
L'invention concerne un composé à base d'acide hydroxamique à sulfamate inhibant, entre autres, l'activité de métalloprotéase matricielle, ainsi qu'un procédé de préparation dudit composé, des composés intermédiaires utiles à ces synthèses, et un traitement consistant à administrer à un hôte présentant un état associé à une activité de métalloprotéase matricielle pathologique une quantité d'un composé à base d'acide hydroxamique à sulfamate suffisante à inhiber l'enzyme MMP.
Boehm Terri L.
Carroll Jeffery N.
de Crescenzo Gary A.
Kassab Darren J.
Mischke Deborah A.
G.d. Searle & Co.
Osler Hoskin & Harcourt Llp
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