C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/48 (2006.01) A61K 31/505 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 403/14 (2006.01)
Patent
CA 2710118
The invention relates to compounds of formula (I). Said compounds are useful as inhibitors of ZAP-70 for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immuno logically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
La présente invention concerne des composés de formule (I), dans laquelle X, R1, R2, R3, R8, R9 sont tels que définis dans la description et les revendications. Lesdits composés sont utiles en tant qu'inhibiteurs de ZAP-70 pour le traitement et la prophylaxie de troubles immunologiques, inflammatoires, auto-immuns, allergiques, et de maladies immunologiques. L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés, la préparation de tels composés ainsi que leur utilisation en tant que médicaments.
Drewes Gerard
Harrison Richard John
Kruse Ulrich
Major Jeremy
Middlemiss David
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Cellzome Limited
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