Sulfamoyl-2-benzofurancarboxylic acid derivative

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

260/361.1, 260/3

C07D 307/85 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 1333603

Highly effective diuretic antihypertensives, i.e., sulfamoyl-2-benzofurancarboxylic acid derivatives which are classified as loop diuretics with less adverse side-effects and which can be administered orally, have the formula Image wherein R is hydrogen or a protecting group; R1 and R2 are the same or different and each is hydrogen, lower alkyl, 4- to 7-membered cycloalkyl, optionally substituted phenyl, phenyl-lower alkyl, lower alkoxy- carbonyl, or morpholino-lower alkyl, or R1 and R2 taken together with the adjacent nitrogen atom may form an optionally substituted 5- or 6-membered heterocycle which may have an additional one or more hetero atoms; and X and X' are each independently hydrogen or halogen.

577580

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