C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) C07K 16/40 (2006.01) C12N 9/16 (2006.01) C12N 15/63 (2006.01) C12Q 1/44 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2433681
Novel sulfatases and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including various diagnostic and therapeutic agent screening applications. Also provided are methods of inhibiting tumor-induced angiogenesis and methods of treating disease conditions associated therewith, particularly by administering an inhibitor of a subject sulfatase.
La présente invention concerne, d'une part des sulfatases et des polypeptides en relation avec ces sulfatases, et d'autre part des compositions à base d'acides nucléiques les codant. Ces sulfatases et compositions à base d'acides nucléiques conviennent particulièrement pour diverses applications et notamment la recherche systématique d'agents diagnostics et thérapeutiques. La présente invention concerne des procédures permettant d'inhiber l'angiogenèse induite par la tumeur et des procédés permettant de traiter des états pathologiques associés à cette angiogenèse, notamment par administration d'un inhibiteur d'une sulfatase considérée.
Hemmerich Stefan
Rosen Steven D.
Tomita Megumi
Fetherstonhaugh & Co.
The Regents Of The University Of California
Thios Biotechnology Inc.
Thios Pharmaceuticals Inc.
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