C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 3/04 (2006.01) A61K 31/7016 (2006.01) A61K 31/702 (2006.01) A61P 7/02 (2006.01) A61P 9/00 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) C07H 3/06 (2006.01) C07H 5/04 (2006.01) C07H 11/00 (2006.01)
Patent
CA 2557989
The invention relates to compounds which are polysufated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase; methods for the preparation of the compounds; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti- inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment, lowering of blood triglyceride levels and inhibition of cardiovascular disease of a mammalian subject.
L'invention concerne des composés qui sont des dérivés d'oligosaccharide polysulfaté présentant une activité en tant qu'inhibiteurs de protéines se liant à l'héparane sulfate et en tant qu'inhibiteurs de l'héparanase ; des méthodes de préparation de ces composés ; des compositions comprenant ces composés et l'utilisation de ces composés et de leurs compositions dans les traitements anti-angiogénique, antimétastatique, anti-inflammatoire, antimicrobien, anticoagulant et/ou antithrombotique, l'abaissement des taux de triglycérides dans le sang et l'inhibition de la maladie cardiovasculaire d'un mammifère.
Fairweather Jon Krueger
Ferro Vito
Karoli Tomislav
Liu Ligong
Goudreau Gage Dubuc
Progen Industries Limited
Progen Pharmaceuticals Limited
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