Sulfated oligosaccharide derivatives

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 3/04 (2006.01) A61K 31/7016 (2006.01) A61K 31/702 (2006.01) A61P 7/02 (2006.01) A61P 9/00 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) C07H 3/06 (2006.01) C07H 5/04 (2006.01) C07H 11/00 (2006.01)

Patent

CA 2557989

The invention relates to compounds which are polysufated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase; methods for the preparation of the compounds; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti- inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment, lowering of blood triglyceride levels and inhibition of cardiovascular disease of a mammalian subject.

L'invention concerne des composés qui sont des dérivés d'oligosaccharide polysulfaté présentant une activité en tant qu'inhibiteurs de protéines se liant à l'héparane sulfate et en tant qu'inhibiteurs de l'héparanase ; des méthodes de préparation de ces composés ; des compositions comprenant ces composés et l'utilisation de ces composés et de leurs compositions dans les traitements anti-angiogénique, antimétastatique, anti-inflammatoire, antimicrobien, anticoagulant et/ou antithrombotique, l'abaissement des taux de triglycérides dans le sang et l'inhibition de la maladie cardiovasculaire d'un mammifère.

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