Sulfated polysaccharide

Details Sulfated polysaccharide Sulfated polysaccharide

C - Chemistry, Metallurgy

07

K

167/185, 530/9,

C07K 9/00 (2006.01) A61K 31/715 (2006.01) A61K 38/14 (2006.01) C08B 37/00 (2006.01) C12P 19/26 (2006.01)

Patent

CA 1338230

A sulfated polysaccharide DS4152 useful as an angiogenesis inhibitor or antitumor agent is provided selectively. As the sodium salt, it has the following physicochemical characteristics. Molecular weight by the gel filtration method: 29,000 3,000. Elemental analysis: C: 24.42 - 25.76%, H: 3.34 - 3.98%, N: 0.51 - 0.89%, S: 10.6 - 11.7% and P: 0.77 - 1.06%. Sugar and protein contents: Sugar content (%): 57 3 (by phenol sulfuric acid method; standard: galactose). Protein content (%): 1 0.5 (by the Lowry-Folin's method; standard: bovine serum albumin). Specific rotatory power [.alpha.] ?: -37° 1° (0.5% aq. solution). Characteristic absorption bands in infrared absorption spectrum: 1240, 840 (shoulder), 810 (cm-1;KBr).

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