A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/433 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 285/10 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2511818
The present invention relates to novel phosphate isosteres. The invention relates to compounds having a sulfhydantoin or a reverse sulfhydantoin moiety, uses thereof, and related methods. The present invention relates to compounds of formula (I) or (II) : or pharmaceutically acceptable salts thereof; wherein Q, T, m, and X are as described herein. These compounds are inhibitors of phosphatases, particularly inhibitors of SHP-2. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing these compounds and compositions in the treatment of various phosphatase mediated diseases such as cancer and autoimmune disorders.
La présente invention concerne de nouveaux isostères phosphate. Cette invention concerne des composés possédant un sulfhydantoïne ou une fraction sulfhydantoïne, des utilisations de ceux-ci et des techniques associées. Ces composés sont représentés par la formule (I) ou (II): (I) ou (II). Cette invention concerne aussi des sels de ces composés répondant aux normes pharmaceutiques. Dans ces formules, Q, T, m et X sont tels que décrits dans les spécifications. Ces composés sont des inhibiteurs de phosphatases, en particulier des inhibiteurs de SHP-2. Cette invention concerne aussi des compositions répondant aux normes pharmaceutiques comprenant ces composés et des techniques d'utilisation de ces composés et de ces compositions dans le traitement de diverses maladies induites par la phosphatase.
Blake James F.
Miknis Gregory F.
Saunders Jeffrey O.
Blake James F.
Miknis Gregory F.
Saunders Jeffrey O.
Smart & Biggar
Vertex Pharmaceuticals Incorporated
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