Sulfonamide compound and crystal thereof

Details Sulfonamide compound and crystal thereof Sulfonamide compound and crystal thereof

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4725 (2006.01) A61P 27/06 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2690753

(S)-1-(4- Chloro-5-isoquinolinesulfonyl)-3-(methylamino)pyrrolidine monohydrochloride and a crystal thereof, and a crystal of the aforementioned monohydrochloride having a major peak or peaks at one or more positions selected from the group consisting of positions where 2 .theta. s are about 13.9°, 21.5°, 21.7°, 22.4°, 22.8°, 24.5° and 35.0° in a powder X-ray diffraction spectrum, which have excellent properties as active ingredient of a medicament for prophylactic and/or therapeutic treatment of glaucoma and the like.

L'invention porte sur un monochlorydrate de (S)-1-(4-chloro-5-isoquinoléinesulfonyl)-3-(méthylamino)pyrolidine et sur un cristal de ce composé, chacun ayant d'excellentes propriétés pour être utilisé en tant que principe actif d'un agent pharmaceutique pour la prévention et/ou le traitement du glaucome ou autre. Le cristal du monochlorohydrate mentionné ci-dessus peut avoir un pic principal à au moins une position choisie dans le groupe constitué par les angles 2? d'environ 13,9°, 21,5°, 21,7°, 22,4°, 22,8°, 24,5° et 35,0° dans des spectres de diffraction des rayons X sur poudre.

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