Sulfonamide compounds and medicinal use thereof

Details Sulfonamide compounds and medicinal use thereof Sulfonamide compounds and medicinal use thereof

C - Chemistry, Metallurgy

07

D

C07D 215/48 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/415 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) C07D 231/56 (2006.01) C07D 235/26 (2006.01) C07D 239/96 (2006.01) C07D 241/52 (2006.01) C07D 249/18 (2006.01) C07D 307/79 (2006.01) C07D 333/54 (2006.01) C07D 333/56 (2006.01) C07D 333/62 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2295239

Sulfonamide compounds represented by the general formula (I) R1-SO2NHCO-A-X- R2, salts thereof, and medicinal compositions containing the same. In said formula, R1 represents alkyl, alkenyl, alkynyl, etc.; A represents an optionally substituted polyheterocyclic group except benzimidazolyl, indolyl, 4,7-dihydrobenz-imidazolyl and 2,3-dihydrobenzoxazinyl; X represents alkylene, oxygen, oxygenated lower alkylene, etc.; and R2 represents optionally substituted aryl, substituted biphenylyl, etc. These compounds are useful in treating diseases curable based on the hypoglycemic effect, and diseases curable based on the cGMP-PDE inhibitory, leiolytic, bronchodilating, vasodilating, smooth muscle cell inhibitory, and antiallergic effects.

L'invention concerne des sulfamides de formule générale (I) R<1>-SO2NHCO-A-X-R<2>, dans laquelle R<1> représente alkyle, alcényle, alcynyle, etc.; A représente un groupe polyhétérocyclique éventuellement substitué, à l'exception du benzimidazolyle, de l'indolyle, du 4,7-dihydrobenzimidazolyle et du 2,3-dihydrobenzoxazinyle; X représente alkylène, oxygène, alkylène inférieur oxygéné, etc.; et R<2> représente aryle éventuellement substitué, biphénylyle substitué, etc.; ainsi que leurs sels et des compositions pharmaceutiques les contenant. Ces composés sont utiles pour traiter les maladies réagissant à leurs différentes activités: action hypoglycémiante, inhibition de la GMPc-phosphodiestérase, décontraction des muscles lisses, bronchodilatation, vasodilatation, inhibition des cellules musculaires lisses et action antiallergique.

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