C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/19 (2006.01) A61K 31/18 (2006.01) A61P 25/28 (2006.01) C07C 311/29 (2006.01) C07D 215/22 (2006.01) C07D 257/04 (2006.01) C07D 263/32 (2006.01) C07D 271/06 (2006.01) C07D 285/06 (2006.01) C07D 295/12 (2006.01)
Patent
CA 2562114
The present invention relates to compounds of the Formula (I), wherein R1, R2, R3, m, and n are as defined. Compounds of the Formula (I) have activity inhibiting production of A.beta.-peptide. The invention also relates to pharmaceutical compositions and methods for treating disorders and diseases, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula (I).
L'invention concerne des composés de formule (I), dans laquelle R?1¿, R?2¿, R?3¿, m et n sont tels que définis dans la description. Ces composés de formule (I) présentent une activité inhibant la production de peptide A.beta.. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés, ainsi que des méthodes de traitement de divers troubles et maladies, notamment les troubles neurodégénératifs et/ou neurologiques, la maladie d'Alzheimer par exemple, chez un mammifère.
Brodney Michael A.
Coffman Karen J.
Pfizer Products Inc.
Smart & Biggar
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