Sulfonamide derivative as a matrix metalloproteinase inhibitor

Details Sulfonamide derivative as a matrix metalloproteinase inhibitor Sulfonamide derivative as a matrix metalloproteinase inhibitor

C - Chemistry, Metallurgy

07

D

C07D 277/68 (2006.01) A61K 31/423 (2006.01) C07D 263/58 (2006.01) C07D 277/74 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2372352

The present invention provides a novel sulfonamide derivative of general formula (I) useful as an inhibitor of matrix metalloproteinase (MMP), its isomers, pharmaceutically acceptable salts thereof and a process for preparing the same. Since the sulfonamide derivatives of the present invention selectively inhibit MMP activity in vitro, the MMP inhibitors comprising the sulfonamide derivatives as an effective ingredient can be practically applied for the prevention and treatment of all sorts of diseases caused by overexpression and overactivation of MMP.

La présente invention concerne un nouveau dérivé sulfonamide de formule (I) utile en tant qu'inhibiteur de métalloprotéinase matricielle (MMP), des sels pharmaceutiquement acceptables de ce dernier et un procédé de préparation associé. Etant donné que le dérivé sulfonamide selon l'invention inhibe sélectivement l'activité de MMP in vitro, on peut, dans la pratique, l'utiliser dans le traitement et la prévention des maladies provoquées par la surexpression de MMP. Formule (I)

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