Sulfonamide derivatives

Details Sulfonamide derivatives Sulfonamide derivatives

C - Chemistry, Metallurgy

07

C

C07C 311/00 (2006.01) A61K 31/18 (2006.01) A61K 31/33 (2006.01) C07C 311/19 (2006.01) C07D 207/34 (2006.01) C07D 213/71 (2006.01) C07D 215/36 (2006.01) C07D 217/22 (2006.01) C07D 233/84 (2006.01) C07D 239/38 (2006.01) C07D 307/64 (2006.01) C07D 307/82 (2006.01) C07D 333/34 (2006.01) C07K 5/06 (2006.01)

Patent

CA 2121523

The present invention is directed to sulfonamide derivatives of the general formula (I): (see formula I) wherein R is C6-14 aryl or a heterocyclic residue each of which may have one or more substituents or the salt thereof. The sulfonamide derivatives show strong inhibitory activity against cysteine protease such as calpain papain, cathepsin B, cathepsin H, cathepsin L. They can be used as remedies for muscular dystrophy, cataract, myocardial infarction, stroke, amyotrophia, osteoporosis, hypercalcemia or the like.

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