Sulfonamide derivatives and drugs containing the same as the...

Details Sulfonamide derivatives and drugs containing the same as the... Sulfonamide derivatives and drugs containing the same as the...

C - Chemistry, Metallurgy

07

C

C07C 311/08 (2006.01) A61K 31/18 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07C 311/21 (2006.01) C07C 311/29 (2006.01) C07C 323/49 (2006.01) C07D 213/38 (2006.01) C07D 213/74 (2006.01) C07D 213/75 (2006.01) C07D 213/76 (2006.01) C07D 213/81 (2006.01) C07D 215/40 (2006.01) C07D 217/02 (2006.01) C07D 217/22 (2006.01) C07D 243/08 (2006.01) C07D 295/12 (2006.01) C07D 295/18 (2006.01) C07D 401/04 (2006.01) C07D 401/1

Patent

CA 2325997

Sulfonamide derivatives represented by general formula (1) or salts thereof, wherein A represents nitrogen, -CH=, etc.; Z represents oxygen, etc.; Ar1 represents aryl, etc.; Ar2 represents alkyl, etc.; Ra represents hydrogen, etc.; Rb represents halogeno, etc.; and Rc represents alkyl, etc. Because of having radical-scavenging effect, gastric secretion-potentiating effect, anti- HP bacterial effect, etc., these compounds are useful as remedies for peptic ulcer.

L'invention concerne des dérivés de sulfonamides représentés par la formule générale (1) ou un de leurs sels. Dans cette formule, A représente azote, -CH=, etc.; Z représente oxygène, etc.; Ar?1¿ représente aryle, etc.; Ar?2¿ représente alkyle, etc.; R?a¿ représente hydrogène, etc.; R?b¿ représente halogéno, etc.; et R?c¿ représente alkyle, etc. Grâce à leur effet de piégeage de radicaux, à leur effet de renforcement de la sécrétion gastrique, à leur effet antibactérien HP, etc., ces composés sont utiles en tant que remèdes contre l'ulcère gastro-duodénal.

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