Sulfonamide derivatives as therapeutic or prophylactic agent...

Details Sulfonamide derivatives as therapeutic or prophylactic agent... Sulfonamide derivatives as therapeutic or prophylactic agent...

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/18 (2006.01) A61K 31/38 (2006.01) A61K 31/381 (2006.01) A61K 31/404 (2006.01) A61K 31/405 (2006.01) A61K 31/41 (2006.01) A61K 31/42 (2006.01) A61K 31/421 (2006.01) A61K 31/422 (2006.01) A61K 31/4245 (2006.01) A61P 13/12 (2006.01) A61P 43/00 (2006.01) C07C 311/19 (2006.01) C07D 209/20 (2006.01) C07D 257/04 (2006.01) C07D 263/32 (2006.01) C07D 271/06 (2006.01) C07D 333/18 (2006.01) C07D 333/34 (2006.01) C07D 403/12 (2006.01) C07D 409/04 (2006.01) C07D 411/04 (2006.01)

Patent

CA 2297011

A composition for treating or preventing glomerulopathy which contains a compound of the formula (I): (see formula I) wherein, for example, R1 and R2 are each independently hydrogen atom, optionally substituted lower alkyl, optionally substituted aralkyl, etc.; R3 is 1,4-phenylene and 2,5-thiophendiyl; R4 is the substituents represented by the formula, etc.: Image wherein R6 is hydrogen atom, optionally substituted amino, etc.; and Y is NHOH or OH, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.

L'invention porte sur un agent thérapeutique ou prophylactique de traitement de la glomérulopathie dont le principe actif est un composé de formule générale (I) dans laquelle par exemple: R<1> et R<2> représentent chacun indépendamment un atome d'hydrogène, un alkyle inférieur facultativement substitué, ou un groupe aralkyle facultativement substitué; R<3> représente 1,4-phénylène ou 2,5-thyophénédiyle; R<4> est un groupe représenté par l'une des formules (a), (b), ou (c), (dans lesquelles R<5> représente un atome d'hydrogène, un amino facultativement substitué, ou analogue); et Y représente NHOH ou OH. Elle porte également sur ses isomères à activité optique, sur ses sels pharmacocompatibles, et sur des hydrates.

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