Sulfonamide derivatives of azolones anti-helicobacter agents

Details Sulfonamide derivatives of azolones anti-helicobacter agents Sulfonamide derivatives of azolones anti-helicobacter agents

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/495 (2006.01) C07D 233/70 (2006.01) C07D 249/12 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2194562

The invention is concerned with the compounds having formula (I) the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Y is CH or N; R1, R2 and R3 each independently are hydrogen or C1-4alkyl; R4 and R5 each independently are hydrogen, halo, C1- 4alkyl, C1-4alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; R6 is C1-4alkyl; or phenyl optionally substituted with halo, C1-4alkylcarbonylamino, C1-4alkyloxy, C1-4alkyl or nitro; Z is C=O or CHOH; and (1) is a radical of formula ((a-1), (a-2), (a-3), (a-4), (a-5), (a- 6), or (a-7). Compositions comprising said compounds, processes for preparing the same and the use of these compounds as a medicine.

Composés de la formule (I), leurs sels d'addition acceptables sur le plan pharmacologique, ainsi que leurs formes isomères sur le plan stéréochimique. Dans cette formule Y représente CH ou N; R?1¿, R?2¿ et R?3¿ représentent chacun indépendamment hydrogène ou alkyle C¿1-4?; R?4¿ et R?5¿ représentent chacun indépendamment hydrogène, halo, alkyle C¿1?-¿4?, alkyloxy C¿1-4?, hydroxy, trifluorométhyle, trifluorométhyloxy ou difluorométhyloxy; R?6¿ représente alkyle C¿1-4?; ou phényle éventuellement substitué par halo, alkylcarbonylamino C¿1-4?, alkyloxy C¿1-4?, alkyle C¿1-4? ou nitro; Z représente C=O ou CHOH; et A 1 représente un radical de formule (b) (a-1), (c) (a-2), (d) (a-3), (e) (a-4), (f) (a-5), (g) (a-6) ou (h) (a-7). L'invention concerne également des compositions comprenant ces composés, des procédés de préparation desdits composés ainsi que l'utilisation de ceux-ci en tant que médicament.

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