Sulfonamide fibrinogen receptor antagonists

Details Sulfonamide fibrinogen receptor antagonists Sulfonamide fibrinogen receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 211/34 (2006.01) A61K 31/195 (2006.01) A61K 31/445 (2006.01) A61K 31/675 (2006.01) C07C 311/06 (2006.01) C07C 311/13 (2006.01) C07D 207/26 (2006.01) C07D 211/22 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01) C07D 409/12 (2006.01) C07D 413/00 (2006.01) C07F 9/547 (2006.01)

Patent

CA 2052073

A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet anti-aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation, having the following structure: (see fig. I) wherein R1 is a piperidinyl moiety R4 is aryl selected from the group consisting of phenyl, pyridyl, thienyl, tetrazole or oxazole, or C1-10 alkyl, or C4-10 aralkyl; Z is 0, (see fig. II), or (see fig. III), where m is an integer from two to six, and pharmaceutically acceptable salts thereof.

Série de dérivés non peptidiques qui sont des antagonistes du récepteur IIb/IIIa du fibrinogène et, ainsi, sont des composés anti-agrégation plaquettaire utiles dans la prévention et le traitement des maladies causées par la formation d'un thrombus, ayant la structure suivante : (voir fig. I) où R1 est une fraction pipéridinyle, R4 est un aryle choisi parmi le groupe constitué des groupements phényle, pyridyle, thiényle, tétrazole ou oxazole, ou un alkyle en C1-10, ou un aralkyle en C4-10; Z est 0, (voir fig. II), ou (voir fig. III), où m est un nombre entier compris entre deux et six, et les sels pharmaceutiquement acceptables de ces derniers.

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