Sulfonamide inhibitors of matrix metalloproteinases

Details Sulfonamide inhibitors of matrix metalloproteinases Sulfonamide inhibitors of matrix metalloproteinases

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) C07D 211/10 (2006.01) C07D 211/14 (2006.01) C07D 211/18 (2006.01) C07D 295/096 (2006.01) C07D 295/155 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2233560

Sulfonamide compounds of the following general formula: (see formula I) are described which are inhibitors of matrix metalloproteinases, particularly stromelysin-1 and gelatinase A (72 kD gelatinase). Also described are methods for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, burns, decubital ulcers, chronic ulcers or wounds, cancer metastasis, tumor angiogenesis, arthritis, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes using the compounds.

L'invention a trait à des composés de sulfamide, inhibiteurs de métalloprotinéases matricielles, notamment la stromélysine-1 et la gélatinase A (gélatinase de 72 kD). Elle concerne également des méthodes faisant appel à ces composés pour le traitement de la sclérose en plaques, de la rupture de la plaque athéroscléreuse, de l'anévrisme aortique, de l'insuffisance cardiaque, de la resténose, de la parodontopathie, de l'ulcération cornéenne, des brûlures, des ulcères du décubitus, d'ulcères chroniques ou de lésions, de métastases cancéreuses, de l'angiogénèse tumorale, de l'arthrite ou d'autres affections auto-immunes ou inflammatoires liées à une invasion leucocytaire des tissus.

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