Sulfonamide interleukin-1.beta. converting enzyme inhibitors

Details Sulfonamide interleukin-1.beta. converting enzyme inhibitors Sulfonamide interleukin-1.beta. converting enzyme inhibitors

C - Chemistry, Metallurgy

07

C

C07C 311/13 (2006.01) A61K 31/18 (2006.01) C07C 311/06 (2006.01) C07C 311/10 (2006.01) C07C 311/19 (2006.01) C07C 311/24 (2006.01) C07D 217/24 (2006.01) C07K 5/06 (2006.01) C07K 5/062 (2006.01) C07K 5/065 (2006.01) C07K 5/068 (2006.01) C07K 5/072 (2006.01) C07K 5/078 (2006.01) C07K 5/083 (2006.01) C07K 5/087 (2006.01) C07K 5/09 (2006.01) C07K 5/093 (2006.01) C07K 5/097 (2006.01) C07K 5/103 (2006.01) C07K 5/107 (2006.01) C07K 5/11 (2006.01) C07K 5/113 (2006.01) C07K 5/117 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2268086

The present invention relates to compounds that are inhibitors of interleukin- 1.beta. converting enzyme that have the Formula (I). This invention also relates to a method of treatment of stroke, reperfusion injury, Alzheimer's disease, shigellosis, inflammatory diseases, and septic shock and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1.beta. converting enzyme.

L'invention concerne des composés inhibiteurs de l'enzyme de conversion de l'interleukine 1 beta , représentés par la formule (I). L'invention se rapporte également à une méthode de traitement d'ictus, de lésions dues à la reperfusion, de la maladie d'Alzheimer, de la shigellose, de maladies inflammatoires et de chocs septiques, et à une composition pharmaceutiquement acceptable qui contienne un composé inhibiteur de l'enzyme de conversion de l'interleukine 1 beta .

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