C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/06 (2006.01) A61K 31/4545 (2006.01) A61P 7/02 (2006.01) C07D 211/56 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/08 (2006.01) C07D 491/08 (2006.01)
Patent
CA 2436774
Sulfonamide lactams of the formula (I) wherein X, R1, R2, R3, R4, R4a, R5, R5a, R6, R6a, R7 and R8 are as described herein, are provided which inhibitors of Factor Xa and are useful as anticoagulants in the treatment of cardiovascular diseases associated with thromboses.
La présente invention concerne des lactames sulfonamide représentés par la formule (I) dans laquelle X, R?1¿, R?2¿, R?3¿, R?4¿, R?4a¿, R?5¿, R?5a¿, R?6¿, R?6a¿, R?7¿ et R?8¿ sont tels que décrits dans les spécifications. Ces composés sont des inhibiteurs du facteur Xa, et ils conviennent comme anticoagulants dans le traitement de maladies cardio-vasculaires associées à des thromboses.
Lawrence R. Michael
O'connor Stephen P.
Shi Yan
Stein Philip P.
Bristol-Myers Squibb Pharma Company
Gowling Lafleur Henderson Llp
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