C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/21 (2006.01) A61K 31/18 (2006.01) A61K 31/421 (2006.01) C07C 317/44 (2006.01) C07C 323/56 (2006.01) C07D 263/32 (2006.01) C07D 271/06 (2006.01) C07D 307/52 (2006.01)
Patent
CA 2495956
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides sulfonamides, and compositions and methods utilizing sulfonamides that are useful in the treatment of diseases by blocking potassium channels associated with the onset or recurrence of the indicated conditions. Exemplary diseases treatable with the compounds, compositions and methods of the invention include sickle cell disease and glaucoma.
La présente invention concerne des composés, des compositions et des procédés utiles dans le traitement de maladies consistant à moduler le flux d'ions potassium à travers les canaux à potassium dont le fonctionnement dépend de la tension. L'invention concerne plus particulièrement des sulfonamides ainsi que des compositions et des procédés impliquant l'utilisation de sulfonamides, qui peuvent être utilisés dans le cadre du traitement de maladies par blocage des canaux à potassium associés à l'apparition ou à la persistance des états pathologiques indiqués. Les maladies qui peuvent être traitées au moyen de ces composés, compositions et procédés sont par exemple la drépanocytose et le glaucome.
Atkinson Robert Nelson
Mcnaughton-Smith Grant Andrew
Reed Aimee D.
Icagen Inc.
Ridout & Maybee Llp
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