Sulfonamides having antiangiogenic and anticancer activity

Details Sulfonamides having antiangiogenic and anticancer activity Sulfonamides having antiangiogenic and anticancer activity

C - Chemistry, Metallurgy

07

C

C07C 311/08 (2006.01) A61K 31/196 (2006.01) A61K 31/277 (2006.01) A61K 31/381 (2006.01) A61K 31/404 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/433 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61P 35/00 (2006.01) C07C 311/13 (2006.01) C07C 311/21 (2006.01) C07C 311/29 (2006.01) C07C 311/37 (2006.01) C07C 311/44 (2006.01) C07C 311/46 (2006.01) C07C 317/28 (2006.01) C07C 323/25 (2006.01) C07C 323/49 (2006.01) C07C 323/63 (2006.01) C07C 323/67 (2006.01) C07D 209/08 (2006.01) C07D 213/7

Patent

CA 2501520

Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.

La présente invention concerne des composés ayant une activité d'inhibition de la méthionine aminopeptidase-2 (MetAP2). L'invention a également pour objet des compositions pharmaceutiques comprenant ces composés, des procédés de traitement faisant intervenir l'utilisation de ces composés, des procédés pour inhiber l'angiogenèse, et des procédés pour traiter le cancer.

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