C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/245, 260/266
C07D 295/00 (2006.01) A61K 31/63 (2006.01) C07D 295/14 (2006.01) C07D 295/155 (2006.01) C07D 295/18 (2006.01) C07D 295/192 (2006.01) C07D 413/10 (2006.01)
Patent
CA 1092111
ABSTRACT OF THE DISCLOSURE The invention related to novel sulfonamidobenzoic acid derivatives having the general formula Image wherein R1 denotes a C1-4 alkoxy group or a hydrazino group or an NR4R5 groups wherein R4 and R5 denote each a hydrogen atom or an identical or different C1-4 alkyl group; furthermore R4 may denote an aralkyl or substituted aralkyl group provided that R5 denotes a hydrogen atom; furthermore NR4R5 may denote a morpholine or piperazine ring; R2 and R3 may denote each a hydrogen atom or an identical or different C1-4 aliphatic group; furthermore R2 may denote a cycloaliphatic, aralkyl, substituted aralkyl or amino group provided that R3 denotes a hydrogen atom; furthermore R2 and R3 may denote together with the adjacent nitrogen atom a morpholino ring, an unsubstituted piperazine ring or a substituted piperazine ring, and to their pharmaceutically acceptable acid addition salts. Furthermore, the invention related to a process for preparing these compounds. The novel sulfonamidobenzoic acid derivatives having the general formula I possess significant tyrozine-paralyzing activity and thus they retard the biosynthesis of noradrenaline.
274162
Cseh Gyorgy
Huszti Zsuzsa
Kasztreiner Endre
Kenessey Agnes
Kosary Judit
Fetherstonhaugh & Co.
Richter Gedeon Vegyeszeti Gyar Rt
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