Sulfonamido-macrocycles as tie2 inhibitors

Details Sulfonamido-macrocycles as tie2 inhibitors Sulfonamido-macrocycles as tie2 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 513/08 (2006.01) A61K 31/529 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2590522

The invention relates to sulfonamido-macrocycles according to the general Formula (I) and the salts thereof, to pharmaceutical compositions comprising the sulfonamido-macrocycles and to a method of preparing the sulfonamido- macrocycles as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with angiopoietin and therefore influence Tie2 signalling. (I), wherein R1, R2, R4, A, X, Y, Z and m have the meaning as given in the specification and the claims.

L'invention concerne des macrocycles sulfonamido de formule générale (I) et les sels de ceux-ci, des compositions pharmaceutiques comprenant les macrocycles sulfonamido et un procédé de préparation de ceux-ci, ainsi que l'utilisation de ceux-ci dans la fabrication d'une composition pharmaceutique destinée au traitement de maladies de croissance vasculaire déréglée ou de maladies accompagnées de croissance vasculaire déréglée, les composés interférant de manière efficace avec l'angiopoiétine et influençant ainsi la signalisation de Tie2 (I), dans laquelle R1, R2,R4, A, X, Y, Z et m ont la signification telle que présentée dans la description et les revendications

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