Sulfonated diarylrhodamine dyes as fluorescent labels

Details Sulfonated diarylrhodamine dyes as fluorescent labels Sulfonated diarylrhodamine dyes as fluorescent labels

C - Chemistry, Metallurgy

09

B

C09B 11/24 (2006.01) C09B 11/02 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2429816

Sulfonated diarylrhodamine compounds are useful as fluorescent labels of nucleosides, nucleotides, polynucleotides, and polypeptides. The compounds find particular application in the area of fluorescent nucleic acid analysis, e.g., automated DNA sequencing and fragment analysis, detection of probe hybridization in hybridization arrays, detection of nucleic acid amplification products, and the like.

La présente invention concerne des composés de diarylrhodamine sulfonée utiles en tant que marqueurs fluorescents de nucléosides, nucléotides, polynucléotides et polypeptides. Ces composés trouvent une application particulière dans le domaine de l'analyse de l'acide nucléique fluorescent, par exemple, le séquençage d'ADN automatisé et l'analyse de fragments, la détection d'hybridation de sondes dans des réseaux d'hybridation, la détection de produits d'amplification d'acide nucléique et analogue.

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