Sulfone substituted imidazo ring ethers

Details Sulfone substituted imidazo ring ethers Sulfone substituted imidazo ring ethers

C - Chemistry, Metallurgy

07

D

C07D 471/02 (2006.01) C07D 471/06 (2006.01)

Patent

CA 2549216

Imidazo ring compounds (e.g., imidazoquinolines, 6,7,8,9- tetrahydroimidazoquinolines, imidazonaphthyridines, and 6,7,8,9- tetrahydroimidazonaphthyridines) with a sulfide-, sulfinyl-, or sulfonyl- containing ether substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

La présente invention a trait à des composés cycliques imidazo (par exemple, imidazoquinolines, 6,7,8,9-tétrahydroimidazoquinolines, imidazonaphtyridines, et 6,7,8,9-tétrahydroimidazonaphtyridines) avec un substituant éther contenant des groupes sulfure, sulfinyle, ou sulfonyle à la position 1, à des compositions pharmaceutiques contenant les composés, à des intermédiaires et des procédés de fabrication des composés, et à des procédés d'utilisation de ces composés comme immunomodulateurs pour l'induction de la biosynthèse des cytokines chez des animaux et dans le traitement de maladies comprenant des maladies virales et néoplasiques.

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