Sulfonyl-derivatives as novel inhibitors of histone deacetylase

Details Sulfonyl-derivatives as novel inhibitors of histone deacetylase Sulfonyl-derivatives as novel inhibitors of histone deacetylase

C - Chemistry, Metallurgy

07

D

C07D 295/22 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61K 31/497 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61K 31/551 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07D 207/28 (2006.01) C07D 213/82 (2006.01) C07D 215/36 (2006.01) C07D 233/34 (2006.01) C07D 233/64 (2006.01) C07D 233/84 (2006.01) C07D 233/90 (2006.01) C07D 237/24 (2006.01) C07D 239/42 (2006.01) C07D 239/48 (2006.01) C07D 241/24 (2006.01) C07D 241/26 (2006.01) C07D 243/08 (2006.01) C07D 26

Patent

CA 2476586

This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

Cette invention a trait à de nouveaux composés correspondant à la formule (I), formule dans laquelle n, m, t, R?1¿, R?2¿, R?3¿, R?4¿, L, Q, X, Y, Z et ?_(A)¿ ont des significations définies. Ces nouveaux composés ont une activité enzymatique inhibant l'histone déacétylase. L'invention porte également sur leur préparation, sur des compositions les contenant ainsi que sur leur utilisation comme produit médicinal.

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