C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/36 (2006.01) A61K 31/4706 (2006.01) A61K 31/4709 (2006.01) A61P 25/00 (2006.01) C07D 409/12 (2006.01)
Patent
CA 2690079
New mGluR1 and mGluR5 receptor subtype preferring ligands of formula: (I) and/or salts and/or hydrates and/or solvates thereof, to the processes and intermediates for their preparation, to pharmaceutical compositions containing these compounds and to their use in therapy and/or prevention of a condition which requires modulation of mGluR1 and mGluR5 receptors.FORMULE (I) wherein Ar1 represents an optionally substituted phenyl or heteroaryl group; Ar2 represents a substituted phenyl or an optionally substituted heteroaryl group; R1, R2, R3 and R4 represent independently a substituent selected from hydrogen, halogen, cyano, alkyl, alkoxy, hydroxy, trifluoromethyl, amino, alkylamino, dialkylamino, aminomethyl, alkylaminomethyl, dialkylaminomethyl New mGluR1 and mGluR5 receptor subtype preferring ligands of formula: (I) and/or salts and/or hydrates and/or solvates thereof, to the processes and intermediates for their preparation, to pharmaceutical compositions containing these com-pounds and to their use in therapy and/or prevention of a condition which requires modulation of mGluR1 and mGluR5 receptors. -- FORMULE (I) wherein Ar1 represents an optionally substituted phenyl or heteroaryl group; Ar2 represents a substituted phenyl or an optionally substituted heteroaryl group; R1, R2, R3 and R4 represent independently a substituent selected from hydrogen, halo-gen, cyano, alkyl, alkoxy, hydroxy, trifluoromethyl, amino, alkylamino, dialkylamino, aminomethyl, alkylaminomethyl, dialky-laminomethyl
La présente invention concerne des nouveaux ligands préférant les sous-types de récepteurs mGluRl et mGluR5, de formule (I), et/ou les sels et/ou les hydrates et/ou les solvates desdits. L'invention concerne également les procédés et les intermédiaires pour leur préparation, les compositions pharmaceutiques contenant ces composés, et leur utilisation en thérapie et/ou prévention d'une condition exigeant la modulation des récepteurs mGluRl et mGluR5. FORMULE (I) selon laquelle Ar1 représente un groupe phényle ou hétéroaryle éventuellement substitué; Ar2 représente un groupe phényle substitué ou un groupe hétéroaryle éventuellement substitué; R1, R2, R3 et R4 représentent indépendamment un substituant sélectionné parmi hydrogène, halogène, cyano, alkyle, alcoxy, hydroxy, trifluorométhyle, amino, alkylamino, dialkylamino, aminométhyle, alkylaminométhyle, dialkylaminométhyle.
Bobok Amrita Agnes
Gal Krisztina
Galambos Janos
Keseru Gyorgy
Prauda Ibolya
Fetherstonhaugh & Co.
Richter Gedeon Nyrt.
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