C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/30 (2006.01) A61K 31/404 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2636007
The present invention is directed to compounds of Formula I: which are modulators of the 5-hydroxtryptamine-6 and 5-hydroxytryptamine-2A receptors and which are inhibitors of norepinephrine reuptake. The compounds of the invention, and pharmaceutical composition thereof, are useful in the treatment of disorders related to or associated with the 5-hydroxytryptamine-6 and 5- hydroxtryptamine-2A receptors or with norepinephrine reuptake inhibition.
La présente invention concerne des composés répondant à la formule I : qui sont des modulateurs des récepteurs de la 5-hydroxtryptamine-6 et de la 5-hydroxytryptamine-2A et qui sont des inhibiteurs de recapture de la norépinéphrine. Les composés de la présente invention, et la composition pharmaceutique de ceux-ci, sont utiles dans le traitement de troubles se rapportant ou associés aux récepteurs de la 5-hydroxtryptamine-6 et de la 5-hydroxytryptamine-2A ou à l~inhibition de la recapture de la norépinéphrine.
Bernotas Ronald C.
Coghlan Richard D.
Heffernan Gavin D.
Li Yanfang
Mcdevitt Robert E.
Smart & Biggar
Wyeth
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