Sulfonylamino-derivatives as novel inhibitors of histone...

Details Sulfonylamino-derivatives as novel inhibitors of histone... Sulfonylamino-derivatives as novel inhibitors of histone...

C - Chemistry, Metallurgy

07

D

C07D 211/58 (2006.01) A61K 31/4025 (2006.01) A61K 31/451 (2006.01) A61K 31/4545 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) A61K 45/00 (2006.01) A61P 1/18 (2006.01) A61P 5/00 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 13/08 (2006.01) A61P 13/10 (2006.01) A61P 13/12 (2006.01) A61P 15/00 (2006.01) A61P 17/00 (2006.01) A61P 19/00 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) A61P 43/00 (2006.01) C07D 207/14 (2006.01) C07D 239/42 (2006.01)

Patent

CA 2476186

This invention comprises the novel compounds of formula (I)wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

Cette invention a trait à de nouveaux composés correspondant à la formule (I), formule dans laquelle n, m, t, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, L, Q, X, Y, Z et?_(A)¿ ont des significations définies. Ces nouveaux composés ont une activité enzymatique inhibant l'histone déacétylase. L'invention porte également sur leur préparation, sur des compositions les contenant ainsi que sur leur utilisation comme produit médicinal.

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