Sulfonylamino derivatives which inhibit matrix-degrading...

Details Sulfonylamino derivatives which inhibit matrix-degrading... Sulfonylamino derivatives which inhibit matrix-degrading...

C - Chemistry, Metallurgy

07

D

C07D 275/06 (2006.01) A61K 31/18 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/425 (2006.01) A61K 31/505 (2006.01) C07C 311/19 (2006.01) C07D 209/48 (2006.01) C07D 233/74 (2006.01) C07D 239/96 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2318145

Compounds of formula (I) wherein W is -OH or -NHOH; X is an optionally substituted heterocycle, NR1SO2R2, heterocyclylalkythio, CONR2R3 or NR1COR2; Y, Z, R1-R3 and n are as defined in the application. Compounds (I) are inhibitors of matrix-degrading metalloproteinases and are use for the treatment of related conditions.

L'invention concerne des composés de la formule (I) dans laquelle: W représente -OH ou -NHOH; X représente un hétérocycle éventuellement substitué NR1SO2R2, un hétérocyclylalkythio CONR2R3 ou NR1COR2; Y, Z, R1-R3 et n sont comme définis dans l'application. Les composés (I) sont des inhibiteurs de métalloprotéases de dégradation de matrice et s'utilisent dans le traitement de troubles associés.

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