Sulfonylamino substituted bicyclyl hydroxamic acid derivatives

Details Sulfonylamino substituted bicyclyl hydroxamic acid derivatives Sulfonylamino substituted bicyclyl hydroxamic acid derivatives

C - Chemistry, Metallurgy

07

C

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C07C 311/20 (2006.01) A61K 31/18 (2006.01) A61K 31/34 (2006.01) C07C 311/10 (2006.01) C07C 311/29 (2006.01) C07D 493/08 (2006.01)

Patent

CA 2040319

Sulfonylamino substituted bicyclyl hydroxamic acid derivatives of the formula: Image wherein R1 and R2 each is hydrogen or lower alkyl; R3 is hydrogen, lower alkyl, lower alkoxy, hydroxy or halogen; X is alkylene or alkenylene; Y is methylene or oxygen; and n is 0, 1, or 2 or the pharmaceutically acceptable salt thereof. These compounds have an advanced antagonistic activity to thromboxane A2 (TXa2)-receptor and are useful for the treatment of thrombosis, vasoconstriction, or bronchoconstriction, and the like disease which are induced by TXA2.

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