Sulfonylbenzodiazepinone acetamides as bradykinin antagonists

Details Sulfonylbenzodiazepinone acetamides as bradykinin antagonists Sulfonylbenzodiazepinone acetamides as bradykinin antagonists

C - Chemistry, Metallurgy

07

D

C07D 243/14 (2006.01) A61K 31/5513 (2006.01) A61P 29/00 (2006.01) C07D 213/38 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2501801

Disclosed are compounds, of formula (I) which are bradykinin antagonists and are useful to treat diseases or relieve adverse symptoms associated with disease conditions in mammals mediated by bradykinin. Certain of the compounds exhibit increased potency and are expected to also exhibit an increased duration of action.

L'invention concerne des composés (Formule I) qui sont des antagonistes de la bradykinine et qui sont utilisés pour le traitement de maladies ou le soulagement de symptômes défavorables associés à des états pathologiques chez des mammifères, dont l'origine est attribuée à la bradykinine. Certains de ces composés présentent une puissance accrue et peuvent donc être considérés comme présentant une durée d'action accrue.

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