Sulfonylureidopyrazole derivatives

Details Sulfonylureidopyrazole derivatives Sulfonylureidopyrazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 231/40 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 401/00 (2006.01) C07D 401/04 (2006.01) C07D 403/00 (2006.01) C07D 403/04 (2006.01) C07D 405/00 (2006.01) C07D 405/04 (2006.01) C07D 409/00 (2006.01) C07D 409/04 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07D 417/04 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2247286

Sulfonylureidopyrazole derivatives represented by general formula (1) or (2). Because of having inhibitory effects on endothelin converter enzyme, these compounds are useful in the prevention and treatment of various circulatory diseases, bronchial contraction, nervous disorders, hyposecretion, vascular lesions, various ulcers, etc.

L'invention a trait à des dérivés de sulfonyluréidopyrazole représentés par les formules générales suivantes (1) ou (2). Dans la mesure où ils ont une action inhibitrice sur une enzyme de conversion de l'endothéline, ces composés se révèlent efficaces pour la prévention et le traitement de diverses maladies d'ordre circulatoire, de bronchoconstrictions, de troubles nerveux, de l'hyposécrétion, de lésions vasculaires, et d'ulcères divers, etc.

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