C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 513/08 (2006.01) A61K 31/529 (2006.01) C07C 317/12 (2006.01) C07D 239/04 (2006.01)
Patent
CA 2604353
The invention relates to macrocyclic sulfoximines of the general Formula I : (I), wherein A, X, Y, R1, R2 and R3 have the meaning as given in the specification and the claims, and to salts thereof; to pharmaceutical compositions comprising the macrocyclic sulfoximines, and to a method of preparing the macrocyclic sulfoximines, as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with angiopoietin and therefore influence Tie2 signalling.
L'invention concerne des sulfoximines macrocycliques, de formule générale (I), dans laquelle A, X, Y, R1, R2 et R3 ont les désignations spécifiées dans la description et dans les revendications, et les sels de composés. L'invention concerne en outre des compositions pharmaceutiques comprenant les surlfoximines macrocycliques, et un procédé de préparation des sulfoximines macrocycliques, ainsi que l'utilisation de celles-ci pour la fabrication d'une composition pharmaceutique pour le traitement de maladies de croissance vasculaire déréglée, accompagnées d'une croissance vasculaire déréglée, lesdits composés interférant de manière efficace avec l'angiopoïétine et influençant ainsi la signalisation de Tie2.
Briem Hans
Husemann Manfred
Kettschau Georg
Luecking Ulrich
Schaefer Martina
Bayer Schering Pharma Aktiengesellschaft
Marks & Clerk
LandOfFree
Sulfoximine-pyrimidine macrocycles and the salts thereof , a... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Sulfoximine-pyrimidine macrocycles and the salts thereof , a..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sulfoximine-pyrimidine macrocycles and the salts thereof , a... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1676185