Sulfs as modifiers of the beta catenin pathway and methods...

Details Sulfs as modifiers of the beta catenin pathway and methods... Sulfs as modifiers of the beta catenin pathway and methods...

C - Chemistry, Metallurgy

12

Q

C12Q 1/44 (2006.01) C12Q 1/34 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2535897

Human SULF genes are identified as modulators of the beta catenin pathway, and thus are therapeutic targets for disorders associated with defective beta catenin function. Methods for identifying modulators of beta catenin, comprising screening for agents that modulate the activity of SULF are provided.

L'invention concerne des gènes SULF humains identifiés comme modulateurs de la voie bêta-caténine, qui constituent par conséquent des cibles thérapeutiques pour les troubles liés à une fonction bêta-caténine déficiente. L'invention concerne en outre des procédés d'identification de modulateurs de la bêta-caténine, notamment des procédés de criblage d'agents modulant l'activité des SULF.

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