Sulfur-containing benzimidazole derivatives, process for the...

Details Sulfur-containing benzimidazole derivatives, process for the... Sulfur-containing benzimidazole derivatives, process for the...

C - Chemistry, Metallurgy

07

D

260/314

C07D 235/30 (2006.01)

Patent

CA 1117952

Abstract This invention relates to a process for the preparation of 5(6)- thio-benzimidazole derivatives of the formula I and salts thereof Image (I) (wherein R1 is hydrogen or a group of the formula -COOR5; R5 is C1-4 alkyl; R2 is hydrogen, halogen, C1-6 alkyl, trifluoromethyl or a group of the formula -OR3; R3 is C1-4 alkyl, aryl or aralkyl; R4 stands for hydrogen, C1-6 alkyl, C3-7 cycloalkyl, C3-6 alkenyl, C3-6 alkynyl, or an aryl or aralkyl group whereby the aryl ring of the aryl or aralkyl group may be optionally substituted by one or more halogeno, C1-4 alkyl, nitro, hydroxy, C1-4 alkoxy, C1-4 alkylthio, carboxy or cyano substituent(s) or a group of the formula -S(O)n-R8 in which R8 is lower alkyl; n stands for 0, 1 or 2) which comprises subjecting a compound of the Formula VI Image (VI) to reduction (wherein R1 and R2 are as stated above) and if desired intro- ducing an R4 group being other than hydrogen into the compound of the Formula I thus formed (wherein R1 and R2 are as stated above and R4 is hydrogen) and if desired converting a compound of the Formula I thus obtained into its salt.

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