Sulfur-containing heterocyclic compounds

Details Sulfur-containing heterocyclic compounds Sulfur-containing heterocyclic compounds

C - Chemistry, Metallurgy

07

D

167/208, 167/242

C07D 335/06 (2006.01) C07D 335/08 (2006.01) C07D 337/08 (2006.01) C07D 409/12 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01) C07D 495/04 (2006.01) C07F 9/40 (2006.01) C07F 9/6553 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2006723

The present invention provides a sulfur-containing heterocyclic compound of general formula (I) Image wherein ring A is a benzene ring which may be substituted; R is a hydrogen atom or a hydrocarbon group which may be substituted; B is a carboxyl group which may be esterified or amidated; X is -CH(OH)- or -CO-; k is 0 or 1; and k' is 0, 1 or 2 or a salt thereof. Also, it provides a process for producing the compound (I) or a salt thereof and a pharmaceutical preparation for use in the treatment of osteoporosis comprising the compound (I) or salt thereof. The compounds (I) and salts thereof show excellent bone resorption inhibitory activity.

L'invention porte sur un composé hétérocyclique sulfuré, de formule générale (I) Image - où le cycle A est un noyau benzénique avec ou sans substitution, R est un atome d'hydrogène ou un groupe hydrocarboné avec ou sans substitution, B est un groupe carboxyle pouvant être estérifié ou amidé, X est -CH(OH)- ou -CO-, k est 0 ou 1, et k' est 0, 1 ou 2 - ou sur un de ses sels. L'invention présente également une méthode pour obtenir le composé (I) ou un de ses sels, ainsi qu'un préparation pharmaceutique à base du composé (I) pour le traitement de l'ostéoporose. Le composé (I) et ses sels possèdent d'excellentes propriétés inhibitrices de la résorption osseuse.

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