Sulfur-substituted mevinic acid derivatives

Details Sulfur-substituted mevinic acid derivatives Sulfur-substituted mevinic acid derivatives

C - Chemistry, Metallurgy

07

D

C07D 309/30 (2006.01) A61K 31/22 (2006.01) A61K 31/365 (2006.01) A61K 31/385 (2006.01) C07C 317/44 (2006.01) C07C 317/46 (2006.01) C07C 323/61 (2006.01) C07C 323/62 (2006.01) C07C 323/65 (2006.01) C07D 339/00 (2006.01)

Patent

CA 2046171

HX38 SULFUR-SUBSTITUTED MEVINIC ACIDS Abstract of the Disclosure Image and pharmaceutically acceptable salts thereof possess activity as cell-selective HMG-CoA reductase inhibitors, thus making them useful as antihypercholesterolemic agents. In the above formula, X is hydrogen or -S(O)m-R1 and Y is hydrogen or S(O)n-R2, except that X and Y are not both hydrogen, or one of X and Y is -S-alkyl-SH and the other is hydrogen; Z is Image or Image ; and the remaining symbols are as defined in the specification.

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