C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 305/18 (2006.01) A61K 31/255 (2006.01) A61K 31/335 (2006.01) C07C 305/06 (2006.01) C07C 305/10 (2006.01) C07C 311/17 (2006.01) C07C 317/22 (2006.01) C07C 317/32 (2006.01) C07C 317/36 (2006.01) C07C 317/44 (2006.01) C07C 335/16 (2006.01) C07C 335/18 (2006.01) C07D 307/68 (2006.01) C07D 311/82 (2006.01)
Patent
CA 2139720
The present invention is concerned with novel sulphuric acid esters of sugar alcohols and sugar alcohol-like compounds of the general formula. Image (I) wherein A is the residue of a sugar alcohol or of a derivative thereof devoid of the 1-hydroxy group, or the tris-(hydroxymethyl)methyl residue, with at least one hydroxy group of the residue A being esterified with sulphuric acid; X is -NR1CO-; -NHCONH-; -NHCSNH-; -NHSO2-; -NR1- or -O-; m and p are each independently 0 or 1; R1 is hydrogen, lower-alkyl or hydroxy-lower-alkyl; and B is a system of conjugated multiple bonds; and salts thereof. Furthermore, the invention is concerned with pharma- ceutical preparations containing a compound of general formula 1 or a salt thereof; the use of the compounds of general formula 1 and their salts as medicaments, especially for the treatment and/or prophylaxis of arteriosclerotic changes in the vascular wall, e.g. for the prevention of restenosis after coronary or peri- pheral angioplasty or after bypass operations; for the production of medicaments for the said indications; as well as a process for the manufacture of the compounds of general formula 1 and their salts.
Chucholowski Alexander
Fingerle Jurgen
Iberg Niggi
Marki Hans Peter
Muller Rita
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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