Sulphonamide derivatives

Details Sulphonamide derivatives Sulphonamide derivatives

C - Chemistry, Metallurgy

07

D

C07D 309/12 (2006.01) C07D 309/16 (2006.01) C07D 335/02 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2058651

A B S T R A C T SULPHONAMIDE DERIVATIVES The invention concerns sulphonamide derivatives of the formula I Image wherein R1 includes (1-4C)alkyl; R2 and R3 together form -A2-X2-A3- which defines a ring having 5 to 7 ring atoms, wherein A2 and A3 each is (1-3C)alkylene and X2 is oxy, thio, sulphinyl or sulphonyl; A1 is a direct link to X1 or is (1-3C)alkylene; X1 is oxy, thio, sulphinyl, sulphonyl or imino; Ar is optionally substituted phenylene or Ar is pyridylene; Q is nitrogen or of the formula CR7, wherein R7 includes hydrogen, halogeno, (1-4C)alkyl and (1-4C)alkoxy; each of R4 and R5 is (1-4C)alkyl, (3-4C)alkenyl, (3-4C)alkynyl or optionally substituted phenyl, benzyl or pyridyl, or R5 may be hydrogen; and R6 has any of the meanings defined for R7; or a pharmaceutically-acceptable salt thereof; processes for their manufacture; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.

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