Sulphonamide derivatives, a process for their preparation...

Details Sulphonamide derivatives, a process for their preparation... Sulphonamide derivatives, a process for their preparation...

C - Chemistry, Metallurgy

07

D

260/267.1, 260/3

C07D 295/12 (2006.01) C07D 295/13 (2006.01)

Patent

CA 1166256

ABSTRACT Compounds of the formula (I): R2N-(CH2)n-NH-SO2R1 (I) and salts thereof wherein NR2 represents a piperidyl, pyrrolidyl, or N-methylpiperazyl group any of which may be substituted by one or two methyl groups; R1 is a l-naphthyl group substituted by one or two moieties selected from fluorine, chlorine, bromine, methoxyl, ethoxyl, hydroxyl, acetoxyl, nitro, cyano,amino optionally substituted by one or two C1-6 alkyl groups, methyl, ethyl, carboxyl, methoxycarbonyl, ethoxycarbonyl, acetamido or carboxamido; and n is 2 or 3, pharmaceutical compositions containing them and a process for their preparation. The compounds are useful asanti-arrhythmimic agents having low toxicity.

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