Sulphonamide derivatives and their use in the treatment of...

Details Sulphonamide derivatives and their use in the treatment of... Sulphonamide derivatives and their use in the treatment of...

C - Chemistry, Metallurgy

07

D

C07D 211/96 (2006.01) A61K 31/445 (2006.01) A61K 31/46 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 207/48 (2006.01) C07D 221/24 (2006.01) C07D 223/04 (2006.01) C07D 279/12 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07D 451/02 (2006.01) C07D 451/06 (2006.01) C07D 471/08 (2006.01)

Patent

CA 2258247

Sulphonamide compounds of formula (I) or a salt thereof, wherein: Ar is an optionally substituted mono- or bicyclic aromatic or heteroaromatic ring; R1 and R2 are independently hydrogen, C1-6 alkyl, arylC1-6 alkyl or together with the nitrogen atom to which they are attached form an optionally substituted 5- to 7-membered heterocyclic ring optionally containing a further heteroatom selected from nitrogen, sulphur or oxygen, the nitrogen atom being substituted by hydrogen, C1-6 alkyl, cycloC3-7alkyl, or an optionally substituted aryl, heteroaryl or arylC1-6 alkyl group; R3 is hydrogen or C1-6 alkyl; X is oxygen, sulphur or a bond; n is 2 or 3; and m is 1 or 2, having pharmacological activity, processes for their preparation, compositions containing them and their use in the treatment of CNS disorders.

L'invention concerne des composés du sulfonamide de formule (I), dans laquelle Ar est un noyau aromatique ou hétéro-aromatique mono ou bicyclique, éventuellement substitué; R?1¿ et R?2¿ sont indépendamment hydrogène, alkyle C¿1?-C¿6?, aryl-alkyle C¿1?-C¿6? ou, avec l'atome d'azote sur lequel ils sont fixés, forment un noyau hétérocyclique à 5-7 éléments éventuellement substitué contenant éventuellement un autre hétéroatome choisi entre azote, soufre ou oxygène, l'atome d'azote étant substitué par hydrogène, alkyle C¿1?-C¿6?, cyclo-alkyle C¿3?-C¿7?, ou un groupe aryle, hétéro-aryle ou aryl-alkyle C¿1?-C¿6? éventuellement substitué; R?3¿ est hydrogène ou alkyle C¿1?-C¿6?; X est oxygène, soufre ou une liaison; n est 2 ou 3; et m est 1 ou 2; ou leurs sels; ces composés ayant une activité pharmaceutique. L'invention concerne également des procédés permettant de les préparer et des compositions les contenant, ainsi que leur utilisation dans le traitement des troubles du système nerveux central.

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